Neuraminidase inhibitors for treatment of human and avian strain influenza: A comparative modeling study.

@article{Dobrovolny2011NeuraminidaseIF,
  title={Neuraminidase inhibitors for treatment of human and avian strain influenza: A comparative modeling study.},
  author={Hana M. Dobrovolny and R. Gieschke and Brian E. Davies and Nelson L. Jumbe and Catherine A A Beauchemin},
  journal={Journal of theoretical biology},
  year={2011},
  volume={269 1},
  pages={
          234-44
        }
}
Treatment of seasonal influenza viral infections using antivirals such as neuraminidase inhibitors (NAIs) has been proven effective if administered within 48h post-infection. However, there is growing evidence that antiviral treatment of infections with avian-derived strains even as late as 6 days post-infection (dpi) can significantly reduce infection severity and duration. Using a mathematical model of in-host influenza viral infections which can capture the kinetics of both a short-lived… CONTINUE READING

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