Neuraminidase-induced thrombocytopenia in mice: effects on thrombopoiesis.

  title={Neuraminidase-induced thrombocytopenia in mice: effects on thrombopoiesis.},
  author={Paula E. Stenberg and Jack Levin and Georgiann Baker and Yee-Foong Mok and Larry Corash},
  journal={Journal of cellular physiology},
  volume={147 1},
Previous studies to examine the effects of thrombocytopenia on thrombopoiesis have generally utilized immune-mediated platelet depletion. We have developed a nonimmune model to exclude the possibility that adverse immune-mediated effects have been misinterpreted as the physiological response to stimulation of thrombopoiesis. Thrombopoiesis was examined in mice after induction of thrombocytopenia with a single injection of the nonimmunologic agent neuraminidase (Ndase). Utilizing electron… CONTINUE READING