Neuraminidase amino acids 149 and 347 determine the infectivity and oseltamivir sensitivity of pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1.

@article{Yongkiettrakul2013NeuraminidaseAA,
  title={Neuraminidase amino acids 149 and 347 determine the infectivity and oseltamivir sensitivity of pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1.},
  author={Suganya Yongkiettrakul and Tarangsri Nivitchanyong and Supitcha Pannengpetch and Asawin Wanitchang and Anan Jongkaewwattana and Potjanee Srimanote},
  journal={Virus research},
  year={2013},
  volume={175 2},
  pages={
          128-33
        }
}
Pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1 neuraminidase (NA) differ at two critical residues, positions 149 and 347. Recombinant influenza A viruses were constructed in which these two residues in pandemic influenza A/H1N1 (2009) NA were changed to the corresponding amino acids of avian influenza A/H5N1 NA, and vice versa. Recombinant viruses bearing N1 NA with the oseltamivir resistance mutation H274Y in combination with mutations at residues 149 and 347 were also constructed… CONTINUE READING

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