Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice

@inproceedings{Fougerat2018Neuraminidase1A,
  title={Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice},
  author={Anne Fougerat and Xuefang Pan and Victoria Smutova and Nikolaus Heveker and Christopher W. Cairo and Tarik Issad and Bruno Larriv{\'e}e and Jeffrey A. Medin and Alexey V Pshezhetsky},
  booktitle={Molecular metabolism},
  year={2018}
}
OBJECTIVES Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NEU1-deficient CathAS190A-Neo mice (hypomorph of the NEU1 activator protein, cathepsin A/CathA) on a high-fat diet (HFD) develop hyperglycaemia and insulin resistance faster than wild-type animals. The… CONTINUE READING
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