Neuralized functions as an E3 ubiquitin ligase during Drosophila development

  title={Neuralized functions as an E3 ubiquitin ligase during Drosophila development},
  author={Edward Yeh and Matt Dermer and Cosimo Commisso and Lily Zhou and C.Jane McGlade and Gabrielle L Boulianne},
  journal={Current Biology},
The Notch pathway is a widely studied means of intercellular signaling responsible for the determination of cell fate, cell differentiation, and boundary formation (reviewed in ). The main effectors of this pathway, Notch (N) and Delta (Dl), have been shown to function as a receptor and ligand, respectively. Genetic and phenotypic studies suggest that Neuralized (Neu), a RING finger protein, also plays a role within the N-Dl pathway, although its biochemical function is unknown. Here, we show… CONTINUE READING

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