Neural tube defects: recent advances, unsolved questions, and controversies.

  title={Neural tube defects: recent advances, unsolved questions, and controversies.},
  author={Andrew J Copp and Philip Stanier and Nicholas D. E. Greene},
  journal={The Lancet. Neurology},
  volume={12 8},
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida lesions in utero can diminish neurological dysfunction in children. Primary prevention with folic acid has been enhanced through introduction of mandatory food fortification in some countries, although not yet in the UK. Genetic predisposition accounts for most of the risk of neural tube defects… CONTINUE READING
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  • P De Marco, E Merello, A Consales
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  • 2013

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  • NJ Wald, MR Law, JK Morris, DS. Wald
  • J Nutr 2013; published online April 24. DOI:10…
  • 2013

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