Neural tube defects: prevalence, etiology and prevention.

  title={Neural tube defects: prevalence, etiology and prevention.},
  author={Atsuo Kondo and Osamu Kamihira and Hideo Ozawa},
  journal={International journal of urology : official journal of the Japanese Urological Association},
  volume={16 1},
Spina bifida and anencephaly, the common form of neural tube defects, affect approximately 300 000 newborns each year worldwide. The effectiveness of folic acid supplementation in preventing their occurrence or recurrence has been unambiguous since 1991. In general, the prevalence of these abnormalities has decreased in the past 20 to 30 years because of periconceptional folate supplementation, food fortification in several countries, avoiding exposure to environmental factors, and increased… CONTINUE READING
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