Neural-targeted gene therapy for rodent and primate hemiparkinsonism.

  title={Neural-targeted gene therapy for rodent and primate hemiparkinsonism.},
  author={Robert Anton and Jeffrey H. Kordower and Nigel T. Maidment and Jacob S. Manaster and D J Kane and Stephanie Sch{\"u}ller and Jun Yang and Shahrooz Rabizadeh and Robert H Edwards},
  journal={Experimental neurology},
  volume={127 2},
Expression of the rate-limiting enzyme for catecholamine biosynthesis, tyrosine hydroxylase (TH), via retroviral and plasmid expression vectors improved the efficacy of conditionally immortalized nigral neural cells in ameliorating rodent and nonhuman primate models of Parkinson's disease through neural transplantation. No improvement in rotational behavior occurred when sham transplants or nondopaminergic transplants were performed. Transplantation of the temperature-sensitive immortalized… CONTINUE READING