Neural systems approaches to the neurogenetics of autism spectrum disorders

  title={Neural systems approaches to the neurogenetics of autism spectrum disorders},
  author={Judith Piggot and David Shirinyan and Shirag K. Shemmassian and Samra Vazirian and Maricela Alarc{\'o}n},

Environmental and Genetic Factors in Autism Spectrum Disorders: Special Emphasis on Data from Arabian Studies

This comprehensive review describes the psychotropic and antiepileptic drugs that are currently available as effective pharmacological treatments and provides in-depth knowledge on the concepts related to clinical, diagnostic, therapeutic, and genetic perspectives of ASD.

Convergent synaptic and circuit substrates underlying autism genetic risks

These compiled results reveal that ASD risk genes contribute to proper signaling of the developing gene networks that maintain synaptic and circuit homeostasis, which is fundamental to normal brain development.

Genes associated with autism spectrum disorder

Autoimmune Disorder and Autism

Current diagnosis criteria of these disorders are based on behavior tests, no single biomarker has been clinically accepted, which mainly due to the difficulties for studying cellular and molecular etiology of ASD means that the prevalence of ASD is relatively low therefore sample sizes are usually too small for statistical analysis.

An etiologic classification of autism spectrum disorders.

Differences in gender and clinical and diagnostic features were found when etiology was used to create subtypes of ASD, and this classification could have heuristic importance in the search for an autism gene(s).

Epigenetic approaches to psychiatric disorders

An epigenetic explanation for many characteristics of psychiatric disease is presented, the current literature on the epigenetic mechanisms involved in major psychosis, Alzheimer's disease, and autism spectrum disorders are reviewed, and some future directions in the field of psychiatric epigenomics are described.

An Evo-Devo Approach to Thyroid Hormones in Cerebral and Cerebellar Cortical Development: Etiological Implications for Autism

An evo-devo approach to neocortical evolution among species is fundamental to understand not only the role of thyroid hormones and environmental thyroid disruptors on evolution, development, and organization of the cerebral cortex in mammals but also their role in neurological diseases associated to thyroid dysfunction.

Phenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders

  • D. Beversdorf
  • Medicine, Psychology
    Journal of developmental and behavioral pediatrics : JDBP
  • 2016
The “white paper” presented here articulates the challenges involved and provides suggestions for future solutions to identify a “one-size-fits-all” treatment approach for ASD.

Autism and Genetic Syndromes

Wing introduced the term ‘autism spectrum disorder’, which can be described on the basis of information from three domains: social reciprocity, verbal and non-verbal communication and imagination, and a restricted, stereotyped pattern of interests and activities.



Autism genetics: strategies, challenges, and opportunities

  • B. O’RoakM. State
  • Biology, Psychology
    Autism research : official journal of the International Society for Autism Research
  • 2008
What is known about the relative contributions of various types of genetic variation to ASD is addressed, the obstacles facing gene discovery in this complex disorder are considered, and the common methodologies employed to address these issues are evaluated.

Examination of association of genes in the serotonin system to autism

Variation within genes on the serotonin pathway, particularly HTR3A, may have modest effects on autism risk, and genome-wide linkage scans in autism do not provide strong evidence for linkage to any specific gene within the pathway.

Advances in autism genetics: on the threshold of a new neurobiology

Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.

An autosomal genomic screen for autism.

The strongest multipoint results were for regions on chromosomes 13 and 7, and the highest maximum multipoint heterogeneity LOD (MMLS/het) score is 3.0 at D13S800 under the recessive model.

Autism spectrum disorders: developmental disconnection syndromes

An autosomal genomic screen for autism. Collaborative linkage study of autism.

The first stage of a two-stage genomic screen for autism was carried out on individuals affected with autism from 75 families ascertained through an affected sib-pair, with the strongest multipoint results for regions on chromosomes 13 and 7.

The biological basis of autism

  • J. Piven
  • Psychology, Biology
    Current Opinion in Neurobiology
  • 1997

Examination of AVPR1a as an autism susceptibility gene

Though the AVPR1a gene was tested by screening its exons in 125 independent autistic probands and genotyping two promoter polymorphisms in 65 autism affected sibling pair (ASP) families, there was no nonconservative coding sequence changes and evidence of linkage and of linkage disequilibrium was identified.

Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area

  • R. Schultz
  • Psychology, Biology
    International Journal of Developmental Neuroscience
  • 2005