Neural substrates of latent inhibition: the switching model.

@article{Weiner1990NeuralSO,
  title={Neural substrates of latent inhibition: the switching model.},
  author={Ina Weiner},
  journal={Psychological bulletin},
  year={1990},
  volume={108 3},
  pages={
          442-61
        }
}
  • I. Weiner
  • Published 1 November 1990
  • Psychology, Biology
  • Psychological bulletin
Latent inhibition (LI) refers to decrement in conditioning to a stimulus as a result of its prior nonreinforced preexposure. It is a robust phenomenon that has been demonstrated in a variety of classical and instrumental conditioning procedures and in many mammalian species, including humans. The development of LI is considered to reflect decreased associability of, or attention to, stimuli that predict no significant outcome. The fact that LI is considered to be a reflection of attentional… 
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References

SHOWING 1-10 OF 27 REFERENCES
Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system
  • J. Gray
  • Psychology, Biology
    Behavioral and Brain Sciences
  • 1982
TLDR
It is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system (SHS), the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures.
Functions of the basal ganglia
TLDR
This suggestion is strengthened by evidence that the ‘limbic striatum’ seems enabled by its striatonigral efferents to modulate not only the source of its own dopamine innervation but also that of a large additional striatal region.
Brain Plasticity, Learning, and Memory
TLDR
It is concluded that interrelated parts of the thalamus, isocortex and neostriatum constitute functional systems which have distinct properties which can be related to well established psychological phenomena.
Psychopharmacology : a generation of progress
TLDR
This all-encompassing volume was developed by the American College of Neuropsychopharmacology for the purpose of providing a comprehensive survey of progress in that field, and covers the ethics of the use of the drugs, their biochemical bases, and their clinical utilization.
Latent Inhibition and Conditioned Attention Theory
TLDR
This work focuses on conditioned attention theory as applied to latent inhibition in humans, and some applications of conditioned Attention Theory: learned helplessness and schizophrenia.
THE RETICULAR FORMATION REVISITED
TLDR
Recent investigations suggest that, in addition to these centres, the RF contains nuclei which control the action of the spinal anterior horn cells and of the cerebral cortex.
Serotonin. Current aspects of neurochemistry and function.
  • B. Haber
  • Medicine
    Advances in experimental medicine and biology
  • 1981
TLDR
A way to break the boredom in reading is choosing serotonin current aspects of neurochemistry and function as the reading material.
Progress in experimental personality research
In undergoing this life, many people always try to do and get the best. New knowledge, experience, lesson, and everything that can improve the life will be done. However, many people sometimes feel
Conditioning And Associative Learning
TLDR
The study of conditioning in animals Classical and instrumental conditioning Theoretical analysis of classical conditioning Appetitive and aversive reinforcement Avoidance learning Contiguity and contingency: excitatory and inhibitory conditioning Laws of association Discrimination learning.
...
...