Neural substrates of awakening probed with optogenetic control of hypocretin neurons

  title={Neural substrates of awakening probed with optogenetic control of hypocretin neurons},
  author={Antoine R Adamantidis and Feng Zhang and Alexander M. Aravanis and Karl Deisseroth and Luis de Lecea},
The neural underpinnings of sleep involve interactions between sleep-promoting areas such as the anterior hypothalamus, and arousal systems located in the posterior hypothalamus, the basal forebrain and the brainstem. Hypocretin (Hcrt, also known as orexin)-producing neurons in the lateral hypothalamus are important for arousal stability, and loss of Hcrt function has been linked to narcolepsy. However, it is unknown whether electrical activity arising from Hcrt neurons is sufficient to drive… CONTINUE READING
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