Neural substrate for atrial fibrillation: implications for targeted parasympathetic blockade in the posterior left atrium.

@article{Arora2008NeuralSF,
  title={Neural substrate for atrial fibrillation: implications for targeted parasympathetic blockade in the posterior left atrium.},
  author={Rishi Arora and Joseph S. Ulphani and Roger Villuendas and Jason Ng and Laura Harvey and Sarah Thordson and Firdous Inderyas and Yi Lu and David Gordon and Pablo Denes and Rodney Lennart Greene and Susan E Crawford and Robert De Decker and Alexander R. Morris and Jeffrey J. Goldberger and Alan H. Kadish},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 1},
  pages={
          H134-44
        }
}
The parasympathetic (P) nervous system is thought to contribute significantly to focal atrial fibrillation (AF). Thus we hypothesized that P nerve fibers [and related muscarinic (M(2)) receptors] are preferentially located in the posterior left atrium (PLA) and that selective cholinergic blockade in the PLA can be successfully performed to alter vagal AF substrate. The PLA, pulmonary veins (PVs), and left atrial appendage (LAA) from six dogs were immunostained for sympathetic (S) nerves, P… CONTINUE READING

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