Neural stem cells transplantation in cortex in amousemodel of Alzheimer ' s disease

@inproceedings{QinghuaWang2006NeuralSC,
  title={Neural stem cells transplantation in cortex in amousemodel of Alzheimer ' s disease},
  author={QinghuaWang and Yoshihito Matsumoto and Tokuhisa Shindo and KeisukeMiyake and Atsushi Shindo and Masahiko Kawanishi and Nobuyuki Kawai and Takashi Tamiya and Seigo Nagao},
  year={2006}
}
Objective. The goal of this study was to elucidate the effect of neurospheres (NS) on dementia in the mouse model of nucleus basalis of Meynert (NBM) lesion. Methods. Mouse embryonic stem cell (ES) derived neurospheres were transplanted into the frontal association cortex and barrel field of S1 cortex of C57BL/6 mice 4 weeks after including alesionofNBMbyibotenicacid,whileotherhealthymicethatreceivedEScellsserved as control. Behavioral tests by 8-arm radial maze were conducted 8 weeks after… CONTINUE READING