Neural stem cells directly differentiated from partially reprogrammed fibroblasts rapidly acquire gliogenic competency.

@article{Matsui2012NeuralSC,
  title={Neural stem cells directly differentiated from partially reprogrammed fibroblasts rapidly acquire gliogenic competency.},
  author={Takeshi Matsui and Morito Takano and Kenji Yoshida and Soichiro Ono and Chikako Fujisaki and Yumi Matsuzaki and Yoshiaki Toyama and Masaya Nakamura and Hideyuki Okano and Wado Akamatsu},
  journal={Stem cells},
  year={2012},
  volume={30 6},
  pages={1109-19}
}
Neural stem cells (NSCs) were directly induced from mouse fibroblasts using four reprogramming factors (Oct4, Sox2, Klf4, and cMyc) without the clonal isolation of induced pluripotent stem cells (iPSCs). These NSCs gave rise to both neurons and glial cells even at early passages, while early NSCs derived from clonal embryonic stem cells (ESCs)/iPSCs differentiated mainly into neurons. Epidermal growth factor-dependent neurosphere cultivation efficiently propagated these gliogenic NSCs and… CONTINUE READING
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