Neural stem cell niches: roles for the hyaluronan-based extracellular matrix.

@article{Preston2011NeuralSC,
  title={Neural stem cell niches: roles for the hyaluronan-based extracellular matrix.},
  author={Marnie Preston and Larry S. Sherman},
  journal={Frontiers in bioscience},
  year={2011},
  volume={3},
  pages={1165-79}
}
Neural stem/progenitor cells capable of differentiating into the neurons and glial cells that populate the mammalian central nervous system (CNS) persist in specific neural stem cell niches that regulate stem cell proliferation, survival and differentiation. There is growing evidence that the extracellular matrix within neural stem cell niches is required for neural stem cell maintenance. Here, we review findings supporting a pivotal role for the glycosaminoglycan hyaluronan (HA) and its… CONTINUE READING

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