Neural stem cell implantation extends life in Niemann-Pick C1 mice

@article{Ahmad2010NeuralSC,
  title={Neural stem cell implantation extends life in Niemann-Pick C1 mice},
  author={Iram Ahmad and Robert E. Hunter and Jonathan D. Flax and Evan Y. Snyder and Robert P. Erickson},
  journal={Journal of Applied Genetics},
  year={2010},
  volume={48},
  pages={269-272}
}
In order to evaluate the phenotypic effects of implanted neural stem cells (NSCs) in the mouse model of Niemann-Pick C (NPC) disease, we injected a well-characterized clone of murine NSCs into the cerebella of neonatalNpc1− /− and control mice. The implanted cells survived and were abundant in some regions of the cerebellum. Life span was lengthened in NPC mice with the implanted NSCs. However, the rate of weight gain and subsequent weight loss, resulting from neurodegeneration, was not… 

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