Neural stem cell-derived exosomes mediate viral entry

  title={Neural stem cell-derived exosomes mediate viral entry},
  author={Brian C Sims and Linlin Gu and Alexandre Krendelchtchikov and Qiana L. Matthews},
  booktitle={International journal of nanomedicine},
BACKGROUND Viruses enter host cells through interactions of viral ligands with cellular receptors. Viruses can also enter cells in a receptor-independent fashion. Mechanisms regarding the receptor-independent viral entry into cells have not been fully elucidated. Exosomal trafficking between cells may offer a mechanism by which viruses can enter cells. METHODS To investigate the role of exosomes on cellular viral entry, we employed neural stem cell-derived exosomes and adenovirus type 5 (Ad5… CONTINUE READING

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