Neural stem and progenitor cells in nestin-GFP transgenic mice.

  title={Neural stem and progenitor cells in nestin-GFP transgenic mice.},
  author={John L Mignone and Valery Kukekov and A. M. Chiang and Dennis A. Steindler and Grigori Enikolopov},
  journal={The Journal of comparative neurology},
  volume={469 3},
Neural stem cells generate a wide spectrum of cell types in developing and adult nervous systems. These cells are marked by expression of the intermediate filament nestin. We used the regulatory elements of the nestin gene to generate transgenic mice in which neural stem cells of the embryonic and adult brain are marked by the expression of green fluorescent protein (GFP). We used these animals as a reporter line for studying neural stem and progenitor cells in the developing and adult nervous… CONTINUE READING
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