Neural progenitor cell transplantation promotes neuroprotection, enhances hippocampal neurogenesis, and improves cognitive outcomes after traumatic brain injury.

@article{Blaya2015NeuralPC,
  title={Neural progenitor cell transplantation promotes neuroprotection, enhances hippocampal neurogenesis, and improves cognitive outcomes after traumatic brain injury.},
  author={Meghan O Blaya and Pantelis Tsoulfas and Helen M. Bramlett and W. Dalton Dietrich},
  journal={Experimental neurology},
  year={2015},
  volume={264},
  pages={67-81}
}
Transplantation of neural progenitor cells (NPCs) may be a potential treatment strategy for traumatic brain injury (TBI) due to their intrinsic advantages, including the secretion of neurotrophins. Neurotrophins are critical for neuronal survival and repair, but their clinical use is limited. In this study, we hypothesized that pericontusional transplantation of NPCs genetically modified to secrete a synthetic, human multineurotrophin (MNTS1) would overcome some of the limitations of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Traumatic Brain Injury

Cell transplantation • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 40 references

The therapeutic potential of neural stem cells

Nature Reviews Neuroscience • 2006
View 4 Excerpts
Highly Influenced

Directedmigration of human neural progenitor cells to interleukin - 1 beta is promoted by chemokines stromal cell - derived factor - 1 and monocyte chemotactic factor - 1 in mouse brains

Q. Xu, S. Wang, +8 authors T. Ishida
Transl . Neurodegener . • 2012

Similar Papers

Loading similar papers…