Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.

@article{Diana2010NeuralPA,
  title={Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.},
  author={Valentina Diana and Arianna Ottolina and Francesca Botti and Elena Fumagalli and Eleonora Calcagno and Massimiliano de Paola and Alfredo Cagnotto and Gloria Invernici and Eugenio Agostino Parati and Daniela Curti and Tiziana Mennini},
  journal={Experimental neurology},
  year={2010},
  volume={225 1},
  pages={163-72}
}
In the present study, we investigated whether cultured astrocytes derived from adult neural precursor cells (NPCs) obtained from the subventricular zone (SVZ) of wobbler mice display metabolic traits of the wobbler astrocytes in situ and in primary culture. We also utilized NPC-derived astrocytes as a tool to investigate the involvement of astrocytes in the molecular mechanism of MND focusing on the possible alteration of glutamate reuptake since excitotoxicity glutamate-mediated may be a… CONTINUE READING