Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.

@article{Stacpoole2013NeuralPC,
  title={Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.},
  author={Sybil R.L. Stacpoole and Daniel J. Webber and Bilada Bilican and Alastair D Compston and Siddharthan Chandran and Robin J. M. Franklin},
  journal={Stem cells translational medicine},
  year={2013},
  volume={2 6},
  pages={
          464-72
        }
}
Traditionally, in vitro stem cell systems have used oxygen tensions that are far removed from the in vivo situation. This is particularly true for the central nervous system, where oxygen (O2) levels range from 8% at the pia to 0.5% in the midbrain, whereas cells are usually cultured in a 20% O2 environment. Cell transplantation strategies therefore typically introduce a stress challenge at the time of transplantation as the cells are switched from 20% to 3% O2 (the average in adult organs). We… CONTINUE READING
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