Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals, and hypersensitivity

@article{Demir2013NeuralPI,
  title={Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals, and hypersensitivity},
  author={Ihsan Ekin Demir and K H Sch{\"a}fer and Elke Tieftrunk and Helmut Friess and G{\"u}ralp O Ceyhan},
  journal={Acta Neuropathologica},
  year={2013},
  volume={125},
  pages={491-509}
}
Neural plasticity is not only the adaptive response of the central nervous system to learning, structural damage or sensory deprivation, but also an increasingly recognized common feature of the gastrointestinal (GI) nervous system during pathological states. Indeed, nearly all chronic GI disorders exhibit a disease-stage-dependent, structural and functional neuroplasticity. At structural level, GI neuroplasticity usually comprises local tissue hyperinnervation (neural sprouting, neural, and… CONTINUE READING

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