Neural plasticity in the ageing brain

@article{Burke2006NeuralPI,
  title={Neural plasticity in the ageing brain},
  author={S. Burke and C. Barnes},
  journal={Nature Reviews Neuroscience},
  year={2006},
  volume={7},
  pages={30-40}
}
The mechanisms involved in plasticity in the nervous system are thought to support cognition, and some of these processes are affected during normal ageing. Notably, cognitive functions that rely on the medial temporal lobe and prefrontal cortex, such as learning, memory and executive function, show considerable age-related decline. It is therefore not surprising that several neural mechanisms in these brain areas also seem to be particularly vulnerable during the ageing process. In this review… Expand
1,162 Citations

Paper Mentions

Interventional Clinical Trial
Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting… Expand
ConditionsAge-related Cognitive Decline
InterventionOther
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  • 23
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  • 144
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  • 35
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  • 89
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References

SHOWING 1-10 OF 190 REFERENCES
Hippocampal neurobiological mechanisms of age-related memory dysfunction
  • 146
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
  • 642
  • PDF
Normal aging: regionally specific changes in hippocampal synaptic transmission
  • C. Barnes
  • Psychology, Medicine
  • Trends in Neurosciences
  • 1994
  • 230
Neuronal Changes in Normal Human Aging and Alzheimer's Disease
  • 218
The use of animal models to study the effects of aging on cognition.
  • 383
  • PDF
Life and death of neurons in the aging brain.
  • 1,246
  • PDF
Brain Aging: Changes in the Nature of Information Coding by the Hippocampus
  • 160
  • PDF
Gene-expression profile of the ageing brain in mice
  • 990
  • PDF
...
1
2
3
4
5
...