Neural networks in frontotemporal dementia—A meta-analysis

  title={Neural networks in frontotemporal dementia—A meta-analysis},
  author={Matthias L. Schroeter and Karolina Raczka and Jane Neumann and D. Yves von Cramon},
  journal={Neurobiology of Aging},

Dissociating behavioral disorders in early dementia—An FDG-PET study

Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology

This review explores the advancements in neuroimaging and discusses the phenotypic and pathologic features of behavioral variant frontotemporal dementia, semantic variant primary progressive aphasia, and nonfluent variant primary progressiveness, as seen on structural magnetic resonance imaging and positron emission tomography.

Morphological alterations in frontotemporal dementia

The diagnostic potential of measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more commonly used assessment of grey matter thickness and volume, was explored, and DTI-MRI was better at separating FTD cases from controls than grey matter parameters, and may thus be a promising supplementary imaging tool for the diagnostic work in FTD.

Frontotemporal dementia

The most significant result was the normal performance of 61.9% of patients in praxis exams, which was associated with alterations in temporoparietal perfusion in the SPECT images (p <0.02).

Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review.

A systematic review investigating the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD) demonstrates how fragile the current understanding is regarding the association between bv FTD and prior SMI.

Defining the neuropsychological and neuroimaging phenotype of behavioural variant frontotemporal dementia

A novel battery to examine the bases of psychosis in FTD patients with the C9ORF72 mutation was devised, which demonstrated a specific and unique impairment in the ability to interpret somatosensory proprioceptive information in these patients, which may represent a candidate mechanism for psychosis.



Patterns of brain atrophy in frontotemporal dementia and semantic dementia

Although FTD and SemD are associated with different overall patterns of brain atrophy, regions of gray matter tissue loss in the orbital frontal, insular, and anterior cingulate regions are present in both groups and are suggested to underlie some the behavioral symptoms seen in the two disorders.

International approaches to frontotemporal dementia diagnosis: From social cognition to neuropsychology

Diagnostic approaches to frontotemporal dementia continue to differ from institution to institution, although recent research criteria for FTD represent the first step toward standardizing the approach to this disorder.

Frontotemporal dementia as a neural system disease

Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer’s disease

Numerical scores on neuropsychological tests alone are of limited value in differentiating FTD and Alzheimer’s disease, but performance characteristics and error types enhance the distinction between the two disorders.

Frontotemporal lobar degeneration: demographic characteristics of 353 patients.

These findings show that cohorts of patients can be combined using new research criteria for FTLD and demonstrate striking demographic differences among FTLD subgroups, including frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia.

Neuroanatomy of the self

FTD patients with asymmetric loss of function in the nondominant frontal lobe often exhibit a diminished maintenance of previously learned self-concepts despite intact memory and language, which is important for the maintenance of the self.

Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration

In patients with the frontal variant of frontotemporal lobar degeneration, behavioral abnormalities may vary from apathy with motor slowness to disinhibition with agitation (disinhibited form), and the serotoninergic system dysfunction provides a rationale for therapeutic trials with selective serotonin reuptake inhibitors.