• Corpus ID: 14536008

Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo.

  title={Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo.},
  author={Françoise Berlioz and S Julien and Annick Tsocas and Jacques Chariot and Claude Carb{\'o}n and Robert Farinotti and Claude Roz{\'e}},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={288 3},
Intestinal absorption of beta-lactamine antibiotics (e.g., cefixime and cephalexin) has been shown to proceed through the dipeptide carrier system. In a previous study, nifedipine (NFP), an L-type calcium channel blocker, enhanced the absorption of cefixime in vivo but not in vitro, and it was suggested that neural mechanisms might be involved in the effect of NFP. The aim of the present study was to assess the involvement of the nervous system on the intestinal absorption of cephalexin (CFX… 

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Increased intestinal absorption of cefixime by nifedipine in the rat intestinal perfusion model: evidence for a neural regulation.
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Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system
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Transport Characteristics of Cephalosporin Antibiotics Across Intestinal Brush‐border Membrane in Man, Rat and Rabbit
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