Neural microvascular pericytes contribute to human adult neurogenesis

  title={Neural microvascular pericytes contribute to human adult neurogenesis},
  author={Ramin M. Farahani and saba Rezaei-Lotfi and Mary R Simonian and Munira Xaymardan and Neil Hunter},
  journal={Journal of Comparative Neurology},
  pages={780 - 796}
Consistent adult neurogenic activity in humans is observed in specific niches within the central nervous system. However, the notion of an adult neurogenic niche is challenged by accumulating evidence for ectopic neurogenic activity in other cerebral locations. Herein we interface precision of ultrastructural resolution and anatomical simplicity of accessible human dental pulp neurogenic zone to address this conflict. We disclose a basal level of adult neurogenic activity characterized by glial… 

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

The history of pericyte research, the present techniques used to study pericytes in the brain, and current research advancements to characterize and therapeutically target pericyts in the future are reviewed.

Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes

These findings suggest that the global transcriptional landscape not only shapes the functional cellular identity of pericytes, but also stabilizes lineage memory by silencing the competing neural program within a repressed chromatin state.

Metabolic Coordination of Pericyte Phenotypes: Therapeutic Implications

Knowledge gaps need to be addressed to more effectively harness the opportunity for therapeutic manipulation of pericytes to control pathological outcomes in tissue remodeling, and the association between dysregulated metabolic processes and development ofPericyte pathologies will be highlighted.

Central Nervous System Pericytes Contribute to Health and Disease

The role of PCs in central nervous system health and disease is discussed, considering their origin, multipotency, functions and also dysfunction, focusing on new possible avenues to modulate neuroprotection.

The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic Targets

The reactions of pericytes after IS are described, the potential therapeutic targets and strategies targetingpericytes for IS are summarized, and new treatment ideas for ischemic stroke are provided.

A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology.

PLC-containing cortical organoids (PCCOs) represent a new 'assembloid' model that supports astrocytic maturation as well as SARS-CoV-2 entry and replication in neural tissue; thus, PCCOs serve as an experimental model for neural infection.

A Developmental Perspective on Paragangliar Tumorigenesis

The xenograft models of head and neck paraganglioma demonstrate that mesenchymal-like cells first give rise to a vasculo-angiogenic network, and then self-organize into neuroepithelial-like clusters, a process inhibited by treatment with imatinib.

Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model

The findings highlight that intranasal transplantation of hNSCs benefits cognition through multiple mechanisms, and exhibit the great potential of intranAsal administration of stem cells as a non-invasive therapeutic strategy for AD.



Vascular niche for adult hippocampal neurogenesis

The present data provide the first evidence that adult neurogenesis occurs within an angiogenic niche and may provide a novel interface where mesenchyme‐derived cells and circulating factors influence plasticity in the adult central nervous system.

CNS Microvascular Pericytes Exhibit Multipotential Stem Cell Activity

It is reported here that adult central nervous system capillaries contain a distinct population of microvascular cells, the pericyte that are nestin/NG2 positive and in response to basic fibroblast growth factor (bFGF) differentiate into cells of neural lineage.

Directed glia‐assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood‐barrier function

Primary evidence for an angiogenic response in an elemental neurosensory structure, human dental pulp, following chronic carious insult is provided and support a new paradigm for understanding ang iogenic capacity of neuros Sensory structures and aberrations of this response manifest as neurovasculopathies.

Astroglia induce neurogenesis from adult neural stem cells

These findings reinforce the emerging view that astrocytes have an active regulatory role—rather than merely supportive roles traditionally assigned to them—in the mature central nervous system.

In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain.

The adult human forebrain harbors precursor cells that retain the potential for neuronal production and differentiation in vitro, by culturing samples of temporal lobe under conditions permissive for neuronal differentiation, while exposed to 3H-thymidine.

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

In vitro differentiation, enrichment, and transplantation of neural precursor cells from human ES cells are described, depicting humanES cells as a source of transplantable neural precursors for possible nervous system repair.

Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain

It is found that adult human white-matter progenitor cells (WMPCs) could be passaged as neurospheres in vitro and that these cells generated functionally competent neurons and glia both in vivo and after xenograft to the fetal rat brain.

Neural crest origin of retinal and choroidal pericytes.

It is proposed that capillary PCs and vSMCs in the retina and the optic nerve, both parts of the central nervous system, as well as in the choroid, a tissue of mesodermal origin, derive from the neural crest.

Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain

It is shown for the first time that vascular-secreted guidance factors promote early-migrating interneurons in the intact forebrain in vivo and identify a novel role for vascular-Vegfa in this process.

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

It is shown that successful direct reprogramming of adult human brain pericytes into functional iNs by Ascl1 and Sox2 encompasses transient activation of a neural stem cell-like gene expression program that precedes bifurcation into distinct neuronal lineages.