Neural microvascular pericytes contribute to human adult neurogenesis

@article{Farahani2019NeuralMP,
  title={Neural microvascular pericytes contribute to human adult neurogenesis},
  author={Ramin M. Farahani and saba Rezaei-Lotfi and Mary R Simonian and Munira Xaymardan and Neil Hunter},
  journal={Journal of Comparative Neurology},
  year={2019},
  volume={527},
  pages={780 - 796}
}
Consistent adult neurogenic activity in humans is observed in specific niches within the central nervous system. However, the notion of an adult neurogenic niche is challenged by accumulating evidence for ectopic neurogenic activity in other cerebral locations. Herein we interface precision of ultrastructural resolution and anatomical simplicity of accessible human dental pulp neurogenic zone to address this conflict. We disclose a basal level of adult neurogenic activity characterized by glial… 

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References

SHOWING 1-10 OF 71 REFERENCES

Vascular niche for adult hippocampal neurogenesis

The present data provide the first evidence that adult neurogenesis occurs within an angiogenic niche and may provide a novel interface where mesenchyme‐derived cells and circulating factors influence plasticity in the adult central nervous system.

CNS Microvascular Pericytes Exhibit Multipotential Stem Cell Activity

It is reported here that adult central nervous system capillaries contain a distinct population of microvascular cells, the pericyte that are nestin/NG2 positive and in response to basic fibroblast growth factor (bFGF) differentiate into cells of neural lineage.

Directed glia‐assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood‐barrier function

Primary evidence for an angiogenic response in an elemental neurosensory structure, human dental pulp, following chronic carious insult is provided and support a new paradigm for understanding ang iogenic capacity of neuros Sensory structures and aberrations of this response manifest as neurovasculopathies.

Astroglia induce neurogenesis from adult neural stem cells

These findings reinforce the emerging view that astrocytes have an active regulatory role—rather than merely supportive roles traditionally assigned to them—in the mature central nervous system.

In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrain.

The adult human forebrain harbors precursor cells that retain the potential for neuronal production and differentiation in vitro, by culturing samples of temporal lobe under conditions permissive for neuronal differentiation, while exposed to 3H-thymidine.

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

In vitro differentiation, enrichment, and transplantation of neural precursor cells from human ES cells are described, depicting humanES cells as a source of transplantable neural precursors for possible nervous system repair.

Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain

It is found that adult human white-matter progenitor cells (WMPCs) could be passaged as neurospheres in vitro and that these cells generated functionally competent neurons and glia both in vivo and after xenograft to the fetal rat brain.

Neural crest origin of retinal and choroidal pericytes.

It is proposed that capillary PCs and vSMCs in the retina and the optic nerve, both parts of the central nervous system, as well as in the choroid, a tissue of mesodermal origin, derive from the neural crest.

Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain

It is shown for the first time that vascular-secreted guidance factors promote early-migrating interneurons in the intact forebrain in vivo and identify a novel role for vascular-Vegfa in this process.

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

It is shown that successful direct reprogramming of adult human brain pericytes into functional iNs by Ascl1 and Sox2 encompasses transient activation of a neural stem cell-like gene expression program that precedes bifurcation into distinct neuronal lineages.
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