Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors.

@article{CrespoFacorro2001NeuralMO,
  title={Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors.},
  author={Benedicto Crespo-Facorro and Sergio Paradiso and Nancy C. Andreasen and Daniel S. O'Leary and G. Leonard Watkins and Laura L. Boles Ponto and Richard D. Hichwa},
  journal={JAMA},
  year={2001},
  volume={286 4},
  pages={427-35}
}
CONTEXT Loss of the capacity to experience pleasure (anhedonia) is a core clinical feature of schizophrenia. Although functional imaging techniques have been successful in identifying the neural basis of cognitive impairments in schizophrenia, no attempts to date have been made to investigate neural systems underlying emotional disturbances. OBJECTIVE To study the neural basis of emotional processing in schizophrenia by exploring the pattern of brain responses to olfactory stimuli in patients… CONTINUE READING