Neural mechanisms of addiction: the role of reward-related learning and memory.

  title={Neural mechanisms of addiction: the role of reward-related learning and memory.},
  author={Steven E. Hyman and Robert C. Malenka and Eric J. Nestler},
  journal={Annual review of neuroscience},
Addiction is a state of compulsive drug use; despite treatment and other attempts to control drug taking, addiction tends to persist. Clinical and laboratory observations have converged on the hypothesis that addiction represents the pathological usurpation of neural processes that normally serve reward-related learning. The major substrates of persistent compulsive drug use are hypothesized to be molecular and cellular mechanisms that underlie long-term associative memories in several… 

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