Neural markers of negative symptom outcomes in distributed working memory brain activity of antipsychotic-naive schizophrenia patients.

@article{Nejad2013NeuralMO,
  title={Neural markers of negative symptom outcomes in distributed working memory brain activity of antipsychotic-naive schizophrenia patients.},
  author={Ayna Baladi Nejad and Kristoffer Hougaard Madsen and Bj\orn H Ebdrup and Hartwig R. Siebner and Hans Rasmussen and Bodil Aggern{\ae}s and Birte Yding Glenth\oj and William F. C. Baar{\'e}},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 6},
  pages={1195-204}
}
Since working memory deficits in schizophrenia have been linked to negative symptoms, we tested whether features of the one could predict the treatment outcome in the other. Specifically, we hypothesized that working memory-related functional connectivity at pre-treatment can predict improvement of negative symptoms in antipsychotic-treated patients. Fourteen antipsychotic-naive patients with first-episode schizophrenia were clinically assessed before and after 7 months of quetiapine… CONTINUE READING