Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells.

@article{Ceyhan2008NeuralII,
  title={Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells.},
  author={G{\"u}ralp O Ceyhan and Ihsan Ekin Demir and Burak Altintas and Ulrich Rauch and Gerald Thiel and Michael M{\"u}ller and Nathalia A. Giese and Helmut Friess and K H Sch{\"a}fer},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={374 3},
  pages={442-7}
}
Neural invasion by pancreatic cancer cells (PCC) worsens the prognosis and frequently limits curative resection. We established a novel in-vitro model in which T3M4-PCCs were co-cultured with either isolated myenteric plexus cells (MP) or dorsal root ganglia (DRG) of newborn rats within a three-dimensional extracellular matrix gel. The close vicinity of MP or DRG to T3M4-PCCs induced early morphologic changes on T3M4-PCCs at the migration front prior to the migration process with elongated and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Similar Papers

Loading similar papers…