Neural immunity: Friend or foe?

@article{Gendelman2011NeuralIF,
  title={Neural immunity: Friend or foe?},
  author={Howard E. Gendelman},
  journal={Journal of NeuroVirology},
  year={2011},
  volume={8},
  pages={474-479}
}
  • H. Gendelman
  • Published 1 December 2002
  • Biology
  • Journal of NeuroVirology
The articles compiled in this special edition of Journal of NeuroVirology target a developing field of investigation seeking to uncover how the immune system affects both the pathogenic process and protection against the ravages of neurodegenerative processes. Whether caused by a microbe, trauma, toxic metabolite, autoimmunity, or part of a wide degenerative process, immune dysfunction commonly affects central nervous system (CNS) disease. All together, the work presented here proved to be a… 

EncephalomyelitisProtects against Experimental Autoimmune Complement Factor H, a Marker of Self

It is found that the accumulation of human fH in the brain parenchyma protected neurons from complement opsonization, axonal injury, and leukocyte infiltration.

Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases

Common functions of brain MP in neuroimmunity link highly divergent diseases (for example, human immunodeficiency virus type-one associated dementia, Alzheimer's disease and Parkinson's disease). Research seeks to harness MP inflammatory processes with the intent of developing therapeutic interventions that block neurodegenerative processes and improve the quality of life in affected people.

Complement Factor H, a Marker of Self Protects against Experimental Autoimmune Encephalomyelitis1

It is found that the accumulation of human fH in the brain parenchyma protected neurons from complement opsonization, axonal injury, and leukocyte infiltration, and the data argue for a key regulatory activity offH in neuroprotection and provide novel therapeutic avenues for CNS chronic inflammatory diseases.

Immune Response in Neurological Pathology: Emerging Role of Central and Peripheral Immune Crosstalk

An overview of major immune effector cells and the role of the blood-brain barrier in regard to neurological disorders is provided and targeting central-peripheral immune interactions is proposed as a potential improved therapeutic strategy to overcome failures in clinical translation.

B Cells in Multiple Sclerosis and Virus-Induced Neuroinflammation

The available literature is reviewed to explore the relationship between autoimmune and infectious neuroinflammation with a focus on the involvement of B cells in MS and viral infections of the CNS.

Microglia Mediated Neuroinflammation: Focus on PI3K Modulation

Recent findings about the role of PI3K in the modulation of microglia neuroinflammatory responses linked to neurodegeneration are discussed and a potential therapeutic approach helpful for developing innovative therapeutic strategies in Neurodegenerative diseases is discussed.

Neuro‐immune lessons from an annelid: The medicinal leech

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior

Neuroinflammation.

Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia

This article provides a comprehensive review of the status of Toxoplasma research in schizophrenia, including the limitations and improvements of immune-based assays to detect these infections in humans, and recent discoveries concerning the schizophrenia-Toxoplasm association.
...

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