Neural differentiation in the OTT-6050 mouse teratoma: Enzymatic and immunofluorescence characterization of a tumor fraction showing melanogenesis in neuroepithelial cells

A pigmented tumor fraction, designated IB-9, obtained following cellular dissociation and elutriation procedures applied to the solid transplants of the OTT-6050 mouse teratoma cell line, was characterized enzymatically and by immunofluorescence for the presence of tyrosinase and tyrosine hydroxylase (TH). Enzymatic assays of the pigmented tumors were… CONTINUE READING