Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome

  title={Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome},
  author={Nicole Hellbach and Stefan Christopher Weise and Riccardo Vezzali and Shalaka Dhanraj Wahane and Stefanie Heidrich and Deborah Roidl and Jan Pruszak and Jennifer Susanne Esser and Tanja Vogel},
  booktitle={Human molecular genetics},
Simultaneous generation of neural cells and that of the nutrient-supplying vasculature during brain development is called neurovascular coupling. We report on a transgenic mouse with impaired transforming growth factor β (TGFβ)-signalling in forebrain-derived neural cells using a Foxg1-cre knock-in to drive the conditional knock-out of the Tgfbr2. Although the expression of FOXG1 is assigned to neural progenitors and neurons of the telencephalon, Foxg1(cre/+);Tgfbr2(flox/flox) (Tgfbr2-cKO… CONTINUE READING


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