Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling

  title={Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling},
  author={Maurice Kl{\'e}ber and Hye-Youn Lee and Heiko Wurdak and Johanna Buchstaller and Martin M Riccomagno and Lars M Ittner and Ueli Suter and Douglas J Epstein and Lukas Sommer},
  journal={The Journal of Cell Biology},
  pages={309 - 320}
Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells (eNCSCs) (Lee, H.Y., M. Kleber, L. Hari, V. Brault, U. Suter, M.M. Taketo, R. Kemler, and L. Sommer. 2004. Science. 303:1020-1023). However, during normal development Wnt signaling induces a sensory fate only in a subpopulation of eNCSCs while other cells maintain their stem cell features, despite the presence of Wnt activity. Hence, factors counteracting Wnt signaling must exist. Here, we show… CONTINUE READING


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