Neural crest specification regulated by the helix-loop-helix repressor Id2.

@article{Martinsen1998NeuralCS,
  title={Neural crest specification regulated by the helix-loop-helix repressor Id2.},
  author={Brad J Martinsen and Marianne Bronner-Fraser},
  journal={Science},
  year={1998},
  volume={281 5379},
  pages={988-91}
}
Vertebrate neural crest cells, derived from the neural folds, generate a variety of tissues, such as cartilage, ganglia, and cranial (intramembranous) bone. The chick homolog of the helix-loop-helix transcriptional regulator Id2 is expressed in cranial but not trunk neural folds and subsequently in some migrating cranial neural crest cells. Ectopic expression of Id2 with recombinant retroviruses converted ectodermal cells to a neural crest fate, demonstrating that proper regulation of Id2 is… CONTINUE READING

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