Neural crest origin of mammalian Merkel cells.

@article{Szeder2003NeuralCO,
  title={Neural crest origin of mammalian Merkel cells.},
  author={Viktor Szeder and Milo{\vs} Grim and Zdeněk Halata and Maya Sieber-Blum},
  journal={Developmental biology},
  year={2003},
  volume={253 2},
  pages={
          258-63
        }
}
Here, we provide evidence for the neural crest origin of mammalian Merkel cells. Together with nerve terminals, Merkel cells form slowly adapting cutaneous mechanoreceptors that transduce steady indentation in hairy and glabrous skin. We have determined the ontogenetic origin of Merkel cells in Wnt1-cre/R26R compound transgenic mice, in which neural crest cells are marked indelibly. Merkel cells in whiskers and interfollicular locations express the transgene, beta-galactosidase, identifying… CONTINUE READING
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