Neural crest and cardiovascular development: a 20-year perspective.

  title={Neural crest and cardiovascular development: a 20-year perspective.},
  author={Mary R Hutson and M. J. L. Kirby},
  journal={Birth defects research. Part C, Embryo today : reviews},
  volume={69 1},
BACKGROUND Twenty years ago this year was the first publication describing a region of neural crest cells necessary for normal cardiovascular development. Ablation of this region in chick resulted in persistent truncus arteriosus, mispatterning of the great vessels, outflow malalignments, and hypoplasia or aplasia of the pharyngeal glands. METHODS We begin with a historical perspective and then review the progress that has been made in the ensuing 20 years in determining the direct and… CONTINUE READING


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