Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

@article{JaspersFayer2019NeuralCO,
  title={Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder},
  author={Fern Jaspers-Fayer and Sarah Yao Lin and Elaine Chan and Rhonda Ellwyn and Ryan Lim and John R. Best and Laura Belschner and Donna Lang and Manraj K. S. Heran and Todd S. Woodward and S. Evelyn Stewart},
  journal={NeuroImage : Clinical},
  year={2019},
  volume={24}
}
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References

SHOWING 1-10 OF 60 REFERENCES

Obsessive compulsive disorder in adolescence: an epidemiological study.

In the second part of a two-stage epidemiologic study of obsessive-compulsive symptoms in nonreferred adolescents, clinicians interviewed high school students selected from screening measures…

Neural correlates of symptom dimensions in pediatric obsessive-compulsive disorder: a functional magnetic resonance imaging study.

Reduced activity in neural regions underlying emotional processing, cognitive processing, and motor performance in pediatric subjects with OCD compared with the controls is indicated.

Fronto-striato-limbic hyperactivation in obsessive-compulsive disorder during individually tailored symptom provocation.

Symptom-specific frontal activation points towards a sustained endeavor to suppress exaggerated emotional responses to OCD triggers, and augmented amygdala involvement in patients reflects general emotional hyperarousal.

Neural correlates associated with symptom provocation in pediatric obsessive compulsive disorder after a single session of sham-controlled repetitive transcranial magnetic stimulation

OCD: obsessive–compulsive … disgust? The role of disgust in obsessive–compulsive disorder

How elevated behavioural and biological markers of disgust reported in OCD populations support the need for alternative clinical treatment strategies and theoretical models of OCD are discussed.

Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.

The findings suggest that different obsessive-compulsive symptom dimensions are mediated by relatively distinct components of frontostriatothalamic circuits implicated in cognitive and emotion processing.

The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems.

The reported symptom dimension-specific GM and WM alterations support the hypothesis that OCD is an etiologically heterogeneous disorder, with both overlapping and distinct neural correlates across symptom dimensions.

Obsessive-compulsive disorder patients with washing symptoms show a specific brain network when confronted with aggressive, sexual, and disgusting stimuli

Evidence is furnished that OCD patients with washing symptoms show a different pattern of processing of aggressive and disgusting stimuli at the brain level, and the implicated networks involved suggest that OCD Patients have a more self-referential response than in healthy controls.

Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis

Altered functional activation in the same brain regions of affective and cognitive cortico-striatal-thalamic circuits as for adult OCD patients despite some variations in the direction of activation difference is indicated.

fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder.

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