Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies

  title={Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies},
  author={Alexander Rasgon and Wh Lee and Evan Leibu and Angela R. Laird and David C. Glahn and Wayne K. Goodman and Sophia Frangou},
  journal={European Psychiatry},
  pages={25 - 32}

Aberrant functional connectivity of neural circuits associated with thought-action fusion in patients with obsessive–compulsive disorder

The authors' TAF paradigm revealed altered context-dependent engagement of the CSTC and affective networks in OCD patients, suggesting that the neurobiology of cognitive models corresponds to current neuroanatomical models of OCD.

A Systematic Review of Behavioral, Physiological, and Neurobiological Cognitive Regulation Alterations in Obsessive-Compulsive Disorder

The results pointed to the advantageous use of reappraisal and acceptance strategies in contrast to suppression to reduce distress and frequency of intrusive thoughts and might help to improve current guidelines for cognitive therapy.

Altered Resting-State Brain Activity in Schizophrenia and Obsessive-Compulsive Disorder Compared With Non-psychiatric Controls: Commonalities and Distinctions Across Disorders

The hippocampus and PCC are common regions presenting abnormal local spontaneous neuronal activities in both SCZ and OCD, while the abnormality of the striatum can reflect the differences.

Meta-analysis of neurocognitive deficits in unaffected relatives of obsessive-compulsive disorder (OCD): comparison with healthy controls and patients with OCD

  • E. Bora
  • Psychology, Biology
    Psychological Medicine
  • 2020
Findings suggest that abnormalities in inhibition, planning/problem solving and reward-based decision-making are shared features of OCDrel and OCDpt and might be trait markers related to vulnerability for developing OCD.

Task-based fMRI predicts response and remission to exposure therapy in obsessive-compulsive disorder

It is suggested that cingulo-opercular and default mode regions typically implicated in task control and introspective processes, respectively, may be targets for novel treatments that augment the ability of persons with OCD to resolve cognitive conflict and thereby facilitate adherence to EX/RP, increasing the likelihood of remission.

Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD.



Amygdala activation and symptom dimensions in obsessive-compulsive disorder.

The severity of aggression/checking and sexual/religious symptom dimensions were significantly associated with heightened amygdala activation in those with OCD when responding to fearful faces, whereas no such correlations were seen for other symptom dimensions.

Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies.

It is suggested that activations within the dorsal frontoparietal network might be related to patients' efforts to resist the obsessive processes induced by the provocation task.

A meta–analysis of functional neuroimaging in obsessive–compulsive disorder

Structural and Functional Brain Abnormalities in Attention-Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder: A Comparative Meta-analysis.

Shared impairments in inhibitory control, rather than representing a transdiagnostic endophenotype in ADHD and OCD, were associated with disorder-differential functional and structural abnormalities.

Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naïve Patients with Obsessive-Compulsive Disorder

Findings implied that the cardinal feature of OCD, the loss of control, may be attributed to abnormal activities and FC of the ACC and the PCC, as well as contrasting correlations with the severity of OCD symptoms.

Default mode network subsystem alterations in obsessive–compulsive disorder

Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.

Meta-Analysis of Brain Volume Changes in Obsessive-Compulsive Disorder

The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems.

The reported symptom dimension-specific GM and WM alterations support the hypothesis that OCD is an etiologically heterogeneous disorder, with both overlapping and distinct neural correlates across symptom dimensions.