Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration.

@article{Saddoris2011NeuralCO,
  title={Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration.},
  author={Michael P Saddoris and Alice M Stamatakis and Regina M Carelli},
  journal={The European journal of neuroscience},
  year={2011},
  volume={33 12},
  pages={2274-87}
}
During Pavlovian-to-instrumental transfer (PIT), learned Pavlovian cues significantly modulate ongoing instrumental actions. This phenomenon is suggested as a mechanism under which conditioned stimuli may lead to relapse in addicted populations. Following discriminative Pavlovian learning and instrumental conditioning with sucrose, one group of rats (naive) underwent electrophysiological recordings in the nucleus accumbens core and shell during a single PIT session. Other groups, following… CONTINUE READING

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Long-term exposure to cocaine self-administration disrupts the behavioral and neural correlates of Pavlovian second-order conditioning in the nucleus accumbens of rats

  • M. P. Saddoris, C. M. Cameron, J. D. Briley, R. M. Carelli
  • 2010
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