Neural control of intestinal ion transport and paracellular permeability is altered by nutritional status.

@article{Hayden2000NeuralCO,
  title={Neural control of intestinal ion transport and paracellular permeability is altered by nutritional status.},
  author={Ursula L. Hayden and Hannah V. Carey},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={278 6},
  pages={
          R1589-94
        }
}
  • U. L. Hayden, H. V. Carey
  • Published 1 June 2000
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
This study examined the effect of fasting on the neural control of ion transport and paracellular permeability in piglet jejunum. Muscle-stripped tissues from fed or 48-h fasted piglets were mounted in Ussing chambers. Neural blockade with tetrodotoxin (TTX) or antagonists of muscarinic or nicotinic receptors caused reductions in basal short-circuit current that were approximately threefold greater in fasted piglets. The TTX-induced reduction in short-circuit current in fasted piglets was due… 
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References

SHOWING 1-10 OF 39 REFERENCES
Fasting alters basal and stimulated ion transport in piglet jejunum.
TLDR
The results suggest that the absence of luminal nutrition changes the ion transport characteristics of the jejunal epithelium and enhanced ion transport responses to secretory agonists.
Neural blockade in basal and postreceptor-stimulated intestinal transport.
Intrinsic neuroregulation of ion transport in porcine distal jejunum.
TLDR
Results suggest that submucosal noncholinergic neurons tonically limit Cl but not Na absorption, and electrical depolarization of sub mucosal neurons evokes anion secretion which appears to be mediated by cholinergic neuron as well as neurons of unknown chemical identity.
Induction of neurally mediated NaHCO3 secretion by luminal distension in rat ileum.
TLDR
It is demonstrated that distension induces the secretion of Na and HCO3 by the intact ileum, and this secretory process may represent a neurally rather than passively mediated mechanism.
Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum.
TLDR
The results support the existence of a multisynaptic, and tonically active neural pathway which serves to limit intestinal Na+ transport at some point below the maximal absorptive capacity of the mucosa.
Role of the enteric nervous system in the maintained hypersecretion induced by enterotoxin STa in the nutritionally deprived intestine.
TLDR
Dietary deprivation, especially chronic undernutrition, enhances the maximum electrogenic secretion due to STa and creates a new neural path in the submucosal plexus that, when activated by STa, maintains its enhanced secretory action.
Substance P produces sodium and bicarbonate secretion in porcine jejunal mucosa through an action on enteric neurons.
TLDR
Test the hypothesis that SP promotes electrogenic anion secretion in the porcine proximal jejunum, an intestinal segment analogous to the human upper small intestine, and pH-Stat titration experiments revealed that mucosal sheets alkalinized the L bathing medium at a rate twice that of the S medium.
Intestinal secretion after jejunal bypass in the ground squirrel.
TLDR
The results suggest that luminal contents directly influence jejunal secretory capacity in squirrels that either remained active and continued to feed (ACT), or were induced to hibernate (HIB).
Beneficial effects of insulin-like growth factor I on epithelial structure and function in parenterally fed rat jejunum.
On the mode of action of the sympathetic fibres on intestinal fluid transport: evidence for the existence of a glucose-stimulated secretory nervous pathway in the intestinal wall.
TLDR
It is proposed that glucose in some way activates intramural nervous reflex(es) in the intestinal wall and the enhancement of fluid transport induced by adrenergic stimuli is explained by an inhibition of the glucose-activated nervous secretion.
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