Neural control of aging skeletal muscle

@article{Delbono2003NeuralCO,
  title={Neural control of aging skeletal muscle},
  author={Osvaldo Delbono},
  journal={Aging Cell},
  year={2003},
  volume={2}
}
  • O. Delbono
  • Published 1 February 2003
  • Biology, Medicine
  • Aging Cell
Functional and structural decline in the neuromuscular system with aging has been recognized as a cause of impairment in physical performance and loss of independence in the elderly. Alterations in spinal cord motor neurones and at the neuromuscular junction have been identified as evidence of denervation in skeletal muscles from aging mammals, including humans. However, the reciprocal influences of neurones on gene expression in muscle and of muscle on age‐related neurodegeneration are poorly… 

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References

SHOWING 1-10 OF 100 REFERENCES

Skeletal muscle weakness in old age: underlying mechanisms.

Much of the age-associated muscle atrophy and declining strength may be explained by motor unit remodeling which appears to occur by selective denervation of muscle fibers with reinnervation by axonal sprouting from an adjacent innervated unit.

Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases

The results reveal pronounced subtype specificity in the anatomical plasticity and susceptibility to loss of neuromuscular synapses and suggest that degenerative motoneuron diseases involve a common early pathway of selective and progressive synaptic weakening also associated with aging.

Strength and aerobic training attenuate muscle wasting and improve resistance to the development of disability with aging.

The aging-associated muscle wasting is defined as a progressive neuromuscular syndrome that will lower the quality of life in the elderly by decreasing the ability to lift loads and decreasing endurance.

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

A model of persistent, functional myocyte hypertrophy is generated using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1) and suggests clinical strategies for the treatment of age or disease-related muscle frailty.

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.

The results suggest that gene transfer of IGF-I into muscle could form the basis of a human gene therapy for preventing the loss of muscle function associated with aging and may be of benefit in diseases where the rate of damage to skeletal muscle is accelerated.

Age-related changes in expression of the neural cell adhesion molecule in skeletal muscle: a comparative study of newborn, adult and aged rats.

The observed upregulation of NCAM protein in aged muscle supports the assumption that an increasing proportion of muscle fibres are denervated in aged Muscle, and is suggested to correlate with myogenesis.

Effect of partial denervation on motor units in the ageing rat medial gastronemius

Interventions based on the possibility that oxidative stress contributes to sarcopenia.

  • R. Weindruch
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1995
Several research directions appear important to pursue, including the measurement of free radical production in skeletal muscle at diverse ages, antioxidant supplementation as an intervention for retarding the development of sarcopenia, the use of genetically manipulated animal models, and determining the influence of CR on oxidative stress in specific skeletal muscles and individual fibers and neurons therein.

Overexpression of IGF-1 Exclusively in Skeletal Muscle Prevents Age-related Decline in the Number of Dihydropyridine Receptors*

The concept that IGF-1- dependent prevention of age-related decline in DHPR expression is associated with stronger muscle contraction in older transgenic mice is supported.

Motor units: remodeling in aged animals.

  • L. Larsson
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1995
The spatial redistribution of motor unit fibers, higher innervation ratios, and larger motor unit territories in old age indicate an age-related denervation-reinnervation process due to loss of alpha-motoneurones.
...