Neural control of aging skeletal muscle

  title={Neural control of aging skeletal muscle},
  author={Osvaldo Delbono},
  journal={Aging Cell},
  • O. Delbono
  • Published 1 February 2003
  • Biology, Medicine
  • Aging Cell
Functional and structural decline in the neuromuscular system with aging has been recognized as a cause of impairment in physical performance and loss of independence in the elderly. Alterations in spinal cord motor neurones and at the neuromuscular junction have been identified as evidence of denervation in skeletal muscles from aging mammals, including humans. However, the reciprocal influences of neurones on gene expression in muscle and of muscle on age‐related neurodegeneration are poorly… 

Excitation-Contraction Coupling Regulation in Aging Skeletal Muscle

This chapter focuses on skeletal muscle excitation-contraction uncoupling (ECU), external calcium-dependent skeletal muscle contraction, the role of JP-45 and other recently discovered molecules of the muscle T-tubule-sarcoplasmic reticulum junction (triad), the neural influence of skeletal muscle, and the roles of trophic factors–particularly insulin-like growth factor-I (IGF-1).

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

This review addresses the primary events that might lead to NMJ dysfunction with aging, including studies on biomarkers, signaling pathways, and animal models, to positively affect the NMJ through this mechanism and attenuate the age-related progressive impairment in motor function.

A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia

The results provide compelling evidence that susceptibility to sarcopenia is tightly linked to neuromuscular decline in rats and humans, and identify dysregulation of sterol metabolism in the peripheral nervous system as an early event in this process.

Central and Peripheral Neuromuscular Adaptations to Ageing

Combining leading-edge techniques such as high-density surface electromyography (EMG) and improved diagnostic procedures such as functional magnetic resonance imaging (fMRI) or high-resolution electroencephalography (EEG) could be essential to address the unresolved controversies and achieve an extensive understanding of the relationship between neural adaptations and muscle decline.

Respiratory chain deficiency in aged spinal motor neurons☆

Neuromuscular junction transmission failure is a late phenotype in aging mice

Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline

Findings provide direct evidence for NMJ dysfunction as a potential mechanism of age-related muscle dysfunction pathogenesis and severity and suggest that NMJ transmission modulation may serve as a target for therapeutic development for age- related loss of physical function.

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

How studies in Drosophila and mammalian model organisms can each provide distinct advantages to facilitate the understanding of this complex multifactorial condition is outlined and how they can be used to identify suitable therapies are outlined.



Skeletal muscle weakness in old age: underlying mechanisms.

Much of the age-associated muscle atrophy and declining strength may be explained by motor unit remodeling which appears to occur by selective denervation of muscle fibers with reinnervation by axonal sprouting from an adjacent innervated unit.

Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases

The results reveal pronounced subtype specificity in the anatomical plasticity and susceptibility to loss of neuromuscular synapses and suggest that degenerative motoneuron diseases involve a common early pathway of selective and progressive synaptic weakening also associated with aging.

Strength and aerobic training attenuate muscle wasting and improve resistance to the development of disability with aging.

The aging-associated muscle wasting is defined as a progressive neuromuscular syndrome that will lower the quality of life in the elderly by decreasing the ability to lift loads and decreasing endurance.

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

A model of persistent, functional myocyte hypertrophy is generated using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1) and suggests clinical strategies for the treatment of age or disease-related muscle frailty.

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.

The results suggest that gene transfer of IGF-I into muscle could form the basis of a human gene therapy for preventing the loss of muscle function associated with aging and may be of benefit in diseases where the rate of damage to skeletal muscle is accelerated.

Age-related changes in expression of the neural cell adhesion molecule in skeletal muscle: a comparative study of newborn, adult and aged rats.

The observed upregulation of NCAM protein in aged muscle supports the assumption that an increasing proportion of muscle fibres are denervated in aged Muscle, and is suggested to correlate with myogenesis.

Effect of partial denervation on motor units in the ageing rat medial gastronemius

Interventions based on the possibility that oxidative stress contributes to sarcopenia.

  • R. Weindruch
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1995
Several research directions appear important to pursue, including the measurement of free radical production in skeletal muscle at diverse ages, antioxidant supplementation as an intervention for retarding the development of sarcopenia, the use of genetically manipulated animal models, and determining the influence of CR on oxidative stress in specific skeletal muscles and individual fibers and neurons therein.

Overexpression of IGF-1 Exclusively in Skeletal Muscle Prevents Age-related Decline in the Number of Dihydropyridine Receptors*

The concept that IGF-1- dependent prevention of age-related decline in DHPR expression is associated with stronger muscle contraction in older transgenic mice is supported.

Motor units: remodeling in aged animals.

  • L. Larsson
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1995
The spatial redistribution of motor unit fibers, higher innervation ratios, and larger motor unit territories in old age indicate an age-related denervation-reinnervation process due to loss of alpha-motoneurones.