Neural consequences of enviromental enrichment

@article{Praag2000NeuralCO,
  title={Neural consequences of enviromental enrichment},
  author={H. Praag and G. Kempermann and F. Gage},
  journal={Nature Reviews Neuroscience},
  year={2000},
  volume={1},
  pages={191-198}
}
Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans. Although the methods used to measure plastic responses differ, the stimuli required to elicit plasticity are thought to be activity-dependent. In this article, we focus on the neuronal changes that occur in response to complex stimulation by an enriched environment. We emphasize the behavioural and… Expand
View on Nature
dinshi.com
1,552 Citations
Highly Influential Citations
50
Background Citations
548
Methods Citations
24
Results Citations
20

1,552 Citations

Citation Type

Citation Type

Environmental enrichment and the brain.
TLDR
This review shows history of ideas about brain changes in relation to experiential factors and surveys experimental studies of the impact of enriched environment on the brain and behaviour, in adult, aged and injured nervous system. Expand
Training-induced structural changes in the adult human brain
TLDR
The major future challenge is to understand the behavioural consequences and cellular mechanisms underlying training-induced neuroanatomic plasticity in order to adapt treatment strategies for patients with brain injury or neurodegenerative disorders. Expand
The musician's brain as a model of neuroplasticity
TLDR
Here, this work focuses on the functional and anatomical differences that have been detected in musicians by modern neuroimaging methods. Expand
Environment and brain plasticity: towards an endogenous pharmacotherapy.
TLDR
This survey aims to review past and recent work concerning the influence exerted by the environment on brain plasticity processes, with special emphasis on the underlying cellular and molecular mechanisms and starting from experimental work on animal models to move to highly relevant work performed in humans. Expand
Functional implications of hippocampal adult neurogenesis in intellectual disabilities
TLDR
This work reviews the process of generating functional neurons from precursors in the adult brain and its implications in intellectual disability disorders. Expand
Transformation of cortical and hippocampal neural circuit by environmental enrichment
TLDR
It has been half a century since brain volume enlargement was first reported in animals reared in an enriched environment (EE) and exposure to EE has been a useful model system for studying the effects of experience on brain plasticity. Expand
Plasticity and Memory in Cerebral Cortex
Abstract Although long theorized to resist modification to reliably represent the external world, primary sensory cortices actually exhibit profound experience-dependent plasticity across the life… Expand
Activity-Dependent Structural Plasticity of Dendritic Spines
TLDR
The evidence of activity-dependent structural plasticity of dendritic spines in the hippocampus is discussed, focusing on the effects of environmental enrichment, behavioral learning, and in vitro manipulations of neuronal activity leading to synaptic plasticity. Expand
Optimizing brain performance: Identifying mechanisms of adaptive neurobiological plasticity
TLDR
Current behavioral neuroscience approaches offer unique opportunities to evaluate adaptive functions of various neural responses in an attempt to enhance the functional capacity of neural systems. Expand
Neurobehavioral Rehabilitation of Visual Deficits in Older Patients
TLDR
Both behavioral and neuroimaging studies show that this cortical plasticity with negative consequences can be reversed through neurobehavioral restorative training, which results in improved normal and deficient visual processing in aging. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 157 REFERENCES
Enhancement of hippocampal field potentials in rats exposed to a novel, complex environment
The hippocampus plays a crucial role in place learning in rodents and also exhibits a long-term enhancement of synaptic strength and postsynaptic excitability following electrical stimulation of its… Expand
Psychobiology of plasticity: effects of training and experience on brain and behavior
TLDR
Enriched experience and training appear to evoke the same cascade of neurochemical events in causing plastic changes in brain, andufficiently rich experience may be necessary for full growth of species-specific brain characteristics and behavioral potential. Expand
Associative plasticity in striatal transplants.
TLDR
This work has used a lateralized-discrimination task and a transfer-of-training paradigm to demonstrate that recovery requires relearning specific lateralized stimulus-response associations and cannot be explained simply by a generalized training-dependent improvement in motor skill. Expand
Changes in hippocampal neuronal nuclei in response to environmental stimulation.
TLDR
It is proposed that increased variability in nuclear size in the hippocampus reflects an environmentally restricted development of these neurons. Expand
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
TLDR
It is found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates, which indicates that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes. Expand
Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus.
TLDR
It is reported that prenatal stress in rats induced lifespan reduction of neurogenesis in the dentate gyrus and produced impairment in hippocampal-related spatial tasks and pathophysiological hypotheses that propose an early neurodevelopmental origin for psychopathological vulnerabilities in aging are strengthened. Expand
Maternal care, hippocampal synaptogenesis and cognitive development in rats
TLDR
The offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of NMDA receptor subunit and brain-derived neurotrophic factor (BDNF) mRNA, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. Expand
Mechanisms mediating the production of environmentally induced brain changes.
TLDR
Evidence is presented to suggest that the arousal reaction (orienting response) may be a major mediating mechanism by showing that the aroused histories of stimulus-enriched and stimulus-deprived animals are different, and that the properties and consequences of the aroused reaction are such as may account for much current knowledge of environmental effects. Expand
A synaptic model of memory: long-term potentiation in the hippocampus
TLDR
The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength. Expand
Effect of Enriched Environment Rearing on Impairments in Cortical Excitability and Plasticity after Prenatal Alcohol Exposure
TLDR
It is predicted that combinations of interventions will be necessary to completely restore cortical function after exposure of the fetal brain to alcohol and that exposing prenatal alcohol-exposed rats to enriched rearing conditions significantly improves all measured cortical functions but does not restore normal values. Expand
...
1
2
3
4
5
...