Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue

@inproceedings{Erion2016NeuralCA,
  title={Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue},
  author={Renske Erion and Anna N. King and Gang Wu and John B. Hogenesch and Amita Sehgal},
  booktitle={eLife},
  year={2016}
}
Metabolic homeostasis requires coordination between circadian clocks in different tissues. Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. Here we show that free-running oscillations of the fat body clock require clock function in the PDF-positive cells of the fly brain. Interestingly, rhythmic expression of the cytochrome P450 transcripts, sex-specific enzyme 1 (sxe1) and Cyp6a21, which cycle in the fat body… CONTINUE READING
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