Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

@inproceedings{You2015NeuralCR,
  title={Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity},
  author={Xintian A. You and Irena Vlatkovic and Ana Babic and Tristan J. Will and Irina Epstein and Georgi Tushev and G{\"u}ney Akbalik and Mantian Wang and Caspar Glock and Claudia Quedenau and Xi Lin Wang and Jingyi Hou and Hongyu Liu and Wei Sun and Sivakumar Sambandan and Tao Chen and Erin M Schuman and Wei Yea Chen},
  booktitle={Nature Neuroscience},
  year={2015}
}
Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep RNA profiling in different mouse tissues, we observed that circRNAs were substantially enriched in brain and a disproportionate fraction of them were derived from host genes that encode synaptic proteins. Moreover, on the basis of separate profiling of the RNAs localized in neuronal cell bodies and neuropil, circRNAs were, on average, more enriched in the neuropil than their host gene mRNA isoforms. Using high… CONTINUE READING
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