Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors.

@article{Lantujoul1998NeuralCA,
  title={Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors.},
  author={Sylvie Lantu{\'e}joul and Denis Moro and Rob J.A.M. Michalides and Christian G. Brambilla and E. Papasso Brambilla},
  journal={The American journal of surgical pathology},
  year={1998},
  volume={22 10},
  pages={
          1267-76
        }
}
Neural cell adhesion molecules (NCAM) represent specific markers of neuroendocrine (NE) differentiation in lung cancer. Because the polysialic acid form (NCAM-PSA) has reduced adhesion properties, we hypothesized that NCAM-PSA expression could favor metastatic spread. Immunostaining of NCAM and NCAM-PSA were therefore compared in 120 NE lung tumors, including 17 typical carcinoids, 3 atypical carcinoids, 30 large cell NE carcinomas and 70 small cell lung carcinomas, as compared with 25… CONTINUE READING
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