Neural cell adhesion molecule in normal, denervated, and myopathic human muscle

@article{Cashman1987NeuralCA,
  title={Neural cell adhesion molecule in normal, denervated, and myopathic human muscle},
  author={Neil R. Cashman and Jonathan Covault and Robert L. Wollman and Joshua R. Sanes},
  journal={Annals of Neurology},
  year={1987},
  volume={21}
}
The neural cell adhesion molecule (N‐CAM) is a cell‐surface glycoprotein that may mediate some intercellular adhesive interactions in the nervous system. In adult rat muscle, N‐CAM is concentrated near neuromuscular junctions and on satellite cells, but is nearly undetectable in nonsynaptic portions of myofibers. However, N‐CAM is abundant throughout myofibers in denervated and regenerating muscles. Using affinity‐purified antibodies to N‐CAM, we were able to demonstrate a similar distribution… 

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TLDR
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TLDR
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TLDR
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References

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TLDR
The times and places at which N-CAM appears are consistent with its playing several distinct roles in myogenesis, synaptogenesis, and synaptic maintenance, including alignment of secondary along primary myot tubes, early interactions of axons with myotubes, and adhesion of Schwann cells to nerve terminals.

Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro

TLDR
It is reported here that N-CAM antigenic determinants are also present on chick embryo skeletal muscle cells, suggesting that the N- CAM adhesion system can facilitate nerve-muscle as well as nerve-nerve interactions in vitro.

N-CAM at the vertebrate neuromuscular junction

TLDR
The findings indicate that, in muscle, in addition to chemical modulation, cell-surface modulation of N-CAM occurs both in amount and distribution during embryogenesis and in response to denervation.

Specific regulation of N‐CAM/D2‐CAM cell adhesion molecule during skeletal muscle development.

TLDR
N‐CAM/D2-CAM expression is temporally regulated and is expressed only at times of synapse formation consistent with the idea that it may be involved in early nerve‐muscle interactions.

Individual neural cell types express immunologically distinct N-CAM forms

TLDR
A unique form of rat N-CAM recognized by Mab 3G6.41 is found on some but not all neuronal, glial, and muscle cells.

Antibodies that bind specifically to synaptic sites on muscle fiber basal lamina

TLDR
Details of staining patterns, differential susceptibility of antigens to proteolysis, and adsorption experiments showed that the antibodies define at least three different determinants that are present in synaptic but not extrasynaptic BL.

Developmental biology of a neural cell adhesion molecule

TLDR
Experiments in vivo indicate that N-CAM-mediated adhesion is essential to the orderly assembly of the visual system.

Topographic mapping of motor pools onto skeletal muscles

  • M. B. LaskowskiJ. Sanes
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
TLDR
It is suggested that segmental ordering of axons in the nerve, axonal guidance at branch points in the nerves, and positional labels within the muscle may all contribute to the rostrocaudal mapping of motor pools onto muscle.