Neural cell adhesion molecule in normal, denervated, and myopathic human muscle

  title={Neural cell adhesion molecule in normal, denervated, and myopathic human muscle},
  author={N. Cashman and J. Covault and R. L. Wollman and J. Sanes},
  journal={Annals of Neurology},
  • N. Cashman, J. Covault, +1 author J. Sanes
  • Published 1987
  • Biology, Medicine
  • Annals of Neurology
  • The neural cell adhesion molecule (N‐CAM) is a cell‐surface glycoprotein that may mediate some intercellular adhesive interactions in the nervous system. In adult rat muscle, N‐CAM is concentrated near neuromuscular junctions and on satellite cells, but is nearly undetectable in nonsynaptic portions of myofibers. However, N‐CAM is abundant throughout myofibers in denervated and regenerating muscles. Using affinity‐purified antibodies to N‐CAM, we were able to demonstrate a similar distribution… CONTINUE READING
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