Neural cell adhesion molecule in normal, denervated, and myopathic human muscle

@article{Cashman1987NeuralCA,
  title={Neural cell adhesion molecule in normal, denervated, and myopathic human muscle},
  author={Neil R. Cashman and Jonathan Covault and Robert L. Wollman and Joshua R. Sanes},
  journal={Annals of Neurology},
  year={1987},
  volume={21}
}
The neural cell adhesion molecule (N‐CAM) is a cell‐surface glycoprotein that may mediate some intercellular adhesive interactions in the nervous system. In adult rat muscle, N‐CAM is concentrated near neuromuscular junctions and on satellite cells, but is nearly undetectable in nonsynaptic portions of myofibers. However, N‐CAM is abundant throughout myofibers in denervated and regenerating muscles. Using affinity‐purified antibodies to N‐CAM, we were able to demonstrate a similar distribution… Expand
Regenerating and denervated human muscle fibers and satellite cells express neural cell adhesion molecule recognized by monoclonal antibodies to natural killer cells
TLDR
The study concludes that the commercially available monoclonal antibodies to NK cells, Leu‐19 and NKH‐1, are immunocytochemical markers for the satellite cells and the regenerating or newly denervated muscle fibers complementing conventional techniques in the diagnosis of patients with neuromuscular disorders. Expand
Expression pattern of M‐cadherin in normal, denervated, and regenerating mouse muscles
TLDR
It is demonstrated that Mcad is present in satellite cells in normal muscle, and enhanced staining at sites of contact between satellite cells and the parent muscle fiber suggests an additional, spatially restricted expression of Mcad in muscle fibers. Expand
Increased expression of muscular neural cell adhesion molecule in congenital aganglionosis.
TLDR
Abnormal expression of NCAM is a feature of congenital aganglionosis and is likely to be associated with neuromuscular dysfunction within the affected colon. Expand
Neural cell adhesion molecule in aged mouse muscle
TLDR
Investigation of skeletal muscles of mature and old CBF-1 mice showed no difference in neural cell adhesion molecule cellular distribution in mature vs old mice, but in motor nerve of sternomastoid, the number of neural cellAdhesion molecule-positive nerve fibers was increased in old mice. Expand
CD24, a signal-transducing molecule expressed on human B lymphocytes, is a marker for human regenerating muscle
TLDR
Investigation of the expression of the CD24 molecule in developing nerve and muscle, normal adult and various diseased human muscles, strongly suggests that regenerative and fetal myotubes are different with respect to theCD24 molecule expression. Expand
N-CAM is expressed in mature extraocular muscles in a pattern conserved among three species.
TLDR
It is postulate that N-CAM expression may at least be a marker for susceptibility to, if not play a clinically significant role in, the etiology and pathobiology of this disease. Expand
NCAM, vimentin and neonatal myosin heavy chain expression in human muscle diseases
  • Winter, Bornemann
  • Biology, Medicine
  • Neuropathology and applied neurobiology
  • 1999
TLDR
Examination of the expression of vimentin, MHCn, and NCAM using immunohistochemistry in 82 biopsy specimens from muscular dystrophies, inflammatory myopathies, and neurogenic atrophies finds that anti‐vimentin staining detects a broader spectrum of regenerating fibres than anti‐MHCm, at least in the inflammatory myopathy. Expand
Fibre type specific expression of Leu19-antigen and N-CAM in skeletal muscle in various stages after experimental denervation
Leu-19 antigen, which seems to be identical with neural cell adhesion molecule (N-CAM), plays a major role in the innervation of muscle cells, and in adult muscle appears after denervation and duringExpand
Expression of Leu‐19 (CD56, N‐CAM) and nitric oxide synthase (NOS) I in denervated and reinnervated human skeletal muscle
TLDR
It is suggested that innervation is an important factor for selective gene expression and positioning of NOS I and N‐CAM in skeletal muscle and gives practical information for the assessment of the phase and developmental stage of the denervation and reinnervation process. Expand
Anti‐NKH‐1 antibody specifically stains unmyelinated fibres and non‐myelinating Schwann cell columns in humans
TLDR
Investigation of nerve biopsy samples from patients with normal nerve biopsies and a variety of peripheral neuropathies showed that the anti‐NKH‐1 antibody recognizes an isoform of the neural cell adhesion molecule (N‐CAM) that is involved in cell‐cell interactions during embryonic stages and has been detected in skin autonomic nerves. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
Expression of cell adhesion molecule, N-CAM, in diseases of adult human skeletal muscle
TLDR
N-CAM can be regarded as a specific gene product of regenerating myofibres and is an additional marker of these fibres on biopsy of human muscle. Expand
Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle
TLDR
The times and places at which N-CAM appears are consistent with its playing several distinct roles in myogenesis, synaptogenesis, and synaptic maintenance, including alignment of secondary along primary myot tubes, early interactions of axons with myotubes, and adhesion of Schwann cells to nerve terminals. Expand
Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro
TLDR
It is reported here that N-CAM antigenic determinants are also present on chick embryo skeletal muscle cells, suggesting that the N- CAM adhesion system can facilitate nerve-muscle as well as nerve-nerve interactions in vitro. Expand
N-CAM at the vertebrate neuromuscular junction
TLDR
The findings indicate that, in muscle, in addition to chemical modulation, cell-surface modulation of N-CAM occurs both in amount and distribution during embryogenesis and in response to denervation. Expand
Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture
TLDR
It is suggested that binding involving N-CAM may be an important early step in synaptogenesis, and that rapid adhesion mediated by this molecule occurs between spinal cord membranes and muscle cells. Expand
Specific regulation of N‐CAM/D2‐CAM cell adhesion molecule during skeletal muscle development.
TLDR
N‐CAM/D2-CAM expression is temporally regulated and is expressed only at times of synapse formation consistent with the idea that it may be involved in early nerve‐muscle interactions. Expand
Molecular forms of N-CAM and its RNA in developing and denervated skeletal muscle
TLDR
Forms of N-CAM and its RNA in denervated muscle are similar to those seen in perinatal myofibers, suggesting that N- CAM expression is regulated at a pretranslational level. Expand
Individual neural cell types express immunologically distinct N-CAM forms
TLDR
A unique form of rat N-CAM recognized by Mab 3G6.41 is found on some but not all neuronal, glial, and muscle cells. Expand
Development of basal lamina in synaptic and extrasynaptic portions of embryonic rat muscle.
TLDR
An immunofluorescence method is used to compare the development of synaptic and extrasynaptic portions of BL in embryonic rat intercostal muscles to determine whether components are added, lost, or modified as synaptogenesis proceeds. Expand
Antibodies that bind specifically to synaptic sites on muscle fiber basal lamina
TLDR
Details of staining patterns, differential susceptibility of antigens to proteolysis, and adsorption experiments showed that the antibodies define at least three different determinants that are present in synaptic but not extrasynaptic BL. Expand
...
1
2
...