Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors.

@article{Kochlamazashvili2010NeuralCA,
  title={Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors.},
  author={Gaga Kochlamazashvili and Oleg Senkov and Sergei Grebenyuk and Catrina Robinson and Mei-Fang Xiao and Katharina Stummeyer and Rita Gerardy-Schahn and Andreas K. Engel and Larry A. Feig and Alexey Semyanov and Vishnu Suppiramaniam and Melitta Schachner and Alexander Dityatev},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 11},
  pages={4171-83}
}
The neural cell adhesion molecule (NCAM) is the predominant carrier of alpha2,8 polysialic acid (PSA) in the mammalian brain. Abnormalities in PSA and NCAM expression are associated with schizophrenia in humans and cause deficits in hippocampal synaptic plasticity and contextual fear conditioning in mice. Here, we show that PSA inhibits opening of recombinant NMDA receptors composed of GluN1/2B (NR1/NR2B) or GluN1/2A/2B (NR1/NR2A/NR2B) but not of GluN1/2A (NR1/NR2A) subunits. Deficits in NCAM… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

NCAM1 Polysialylation

View 11 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 64 references

NCAM1 and neurocognition in schizophrenia.

Biological psychiatry • 2007
View 3 Excerpts
Highly Influenced

NMDA receptor function: subunit composition versus spatial distribution

Cell and Tissue Research • 2006
View 3 Excerpts
Highly Influenced

Genetic enhancement of learning and memory in mice

Nature • 1999
View 4 Excerpts
Highly Influenced

Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…