Neural cell adhesion molecule L1: signaling pathways and growth cone motility.

@article{Kamiguchi1997NeuralCA,
  title={Neural cell adhesion molecule L1: signaling pathways and growth cone motility.},
  author={Hiroyuki Kamiguchi and Vance P. Lemmon},
  journal={Journal of neuroscience research},
  year={1997},
  volume={49 1},
  pages={
          1-8
        }
}
The neural cell adhesion molecule L1 plays a key role in nervous system development including neuronal migration, neurite growth, and axonal fasciculation. L1 is expressed on most developing axons, and homophilic binding of L1 molecules on adjacent axons is likely to play a key role in axon extension. It is now well documented that a number of second-messenger systems are involved in L1-stimulated neurite growth in vitro. However, it is unclear how L1 homophilic or heterophilic binding trigger… CONTINUE READING
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