Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.

@article{Crippa2011NeuralBO,
  title={Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.},
  author={Jos{\'e} Alexandre S. Crippa and Guilherme Nogueira Derenusson and Thiago Borduqui Ferrari and Lauro Wichert-Ana and Fabio Luis de Souza Duran and Roc{\'i}o Mart{\'i}n-Santos and Marcus Vinicius Sim{\~o}es and Sagnik Bhattacharyya and Paolo Fusar-Poli and Zerrin Atakan and Alaor Santos Filho and Maria Cec{\'i}lia Freitas-Ferrari and Philip K. McGuire and Ant{\^o}nio Waldo Zuardi and Geraldo F. Busatto and Jaime Eduardo Cecilio Hallak},
  journal={Journal of psychopharmacology},
  year={2011},
  volume={25 1},
  pages={121-30}
}
Animal and human studies indicate that cannabidiol (CBD), a major constituent of cannabis, has anxiolytic properties. However, no study to date has investigated the effects of this compound on human pathological anxiety and its underlying brain mechanisms. The aim of the present study was to investigate this in patients with generalized social anxiety disorder (SAD) using functional neuroimaging. Regional cerebral blood flow (rCBF) at rest was measured twice using (99m)Tc-ECD SPECT in 10… CONTINUE READING
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